The present position of the treatment of megaloblastic anaemias.
نویسنده
چکیده
A distinction must be drawn between megaloblastic and macrocytic anaemias. Not all macrocytic anaemias are megaloblastic and not all megaloblastic anaemias are macrocytic. The term macrocytosis refers to the size of red blood cells in the peripheral blood. The mean cell volume of packed red blood cells (haematocrit) may be greater than normal, or the diameters of a proportion of red blood cells may fall outside the normal limits of Price-Jones' curves. Macrocytosis may be present even when the marrow does not contain megaloblasts, e.g. sometimes in diseases of the liver and in leukaemias. Macrospherocytosisi.e. increase in mean volume of red blood cells without a corresponding increase in their mean diameter and may also exist without a megaloblastic marrow, e.g. in some acquired haemolytic anaemias. Megaloblastic anaemias are distinguished in two ways: (a) by finding megaloblasts within the peripheral blood or in the marrow (b) by therapeutic tests with cyanocobalamin (vitamin B12) or folic acid.
منابع مشابه
The vitamin B12 concentrations of serum and urine of normals and of patients with megaloblastic anaemias and other diseases.
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Repeated bone marrow examination was found to be of value in assessing response to treatment in megaloblastic anemia. The objective of this study was monitoring the response of megaloblastics to treatment, concerning the location of neutrophilic myeloperoxidase and myeloperoxidase index (MPXI) and their variation in megaloblastic erythroid progeny. It is possible to follow up megaloblastic ...
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عنوان ژورنال:
- Postgraduate medical journal
دوره 34 394 شماره
صفحات -
تاریخ انتشار 1958